Synonym(s): - Acrofacial dysostosis, Genee-Wiedmann type - Mandibulfacial dysostosis with postaxial limb anomalies - Miller syndrome - POADS - Postaxial acrodysostosis
Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare eye disease - Rare genetic disease - Rare maxillo-facial surgical disease - Rare otorhinolaryngologic disease Entire classification		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities - See
Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive		External references: 1 OMIM reference - See No MeSH references
More Info - Orphanet

Gene symbol	UniProt reference	OMIM reference
DHODH	Q02127	126064

- Abnormal dermatoglyphics
- Autosomal recessive inheritance
- Coloboma of the eyelid
- Downslanted palpebral fissures / anti-mongoloid slanting palpebral fissures
- Ectropion / entropion / eyelid eversion
- Flat cheek bones / malar hypoplasia
- Low set ears / posteriorly rotated ears
- Micrognathia / retrognathia / micrognathism / retrognathism
- Radius anomaly / absence / agenesis / hypoplasia / abnormal radial ray
- Supernumerary nipples / polythelia
- Ulnar / cubital anomaly / absence / agenesis / hypoplasia / abnormal ulnar / cubital ray

- Camptodactyly of some fingers
- Cleft lip and palate
- Conductive deafness / hearing loss
- Congenital cardiac anomaly / malformation / cardiopathy
- Lateral cleft lip / gingival cleft / paramedian nasal cleft
- Structural anomalies of middle ear / ossicles / tympanic cavity
- Syndactyly of fingers / interdigital palm

- Strabismus / squint